Postdoctoral Research Associate
Date: Thursday, July 19 @ 17:41:56 CEST
Topic: Vacancies


4- Year post: Molecular mechanisms of circadian timing in mammals
Salary up to £30,012 depending on experience

Funded by the BBSRC, we seek a dynamic individual to develop transgenic mice in which clock proteins are tagged with fluorescent proteins to permit the study of dynamic interactions of circadian clock elements in key brain and other structures involved in circadian timing. Our goal is to use FRET analysis to characterise the movement and interactions of clock proteins in real time, and examine the effect of clock mutations on mobility of these components. As a key starting position, we will make several lines of transgenic mice using in-frame knock-in to produce clock proteins fused to fluorescent markers. The successful applicant will be required to make the necessary targeting vectors, and will be supported by an Experimental Officer in the transgenic unit who will undertake ES cell selection and produce transgenic animals. The position is based at the University of Manchester, but will involve significant collaboration with Dr Michael Hastings’ laboratory at the Medical Research Council Laboratory of Molecular Biology, Cambridge. You should have good general molecular biological skills, and ideally a background in use of transgenic models as applied to neuroscience or cell biology. You should be willing to learn behavioural techniques, and to make a significant input to the scientific direction of the project.

The circadian laboratories of Professors Loudon and Piggins are part of a large community of circadian biologists at Manchester, with well-equipped facilities for cell imaging, behavioural recording and cell biology. The other Manchester-based grant holder is Professor Ray Boot-Handford, who is also the Director of the Transgenic Facility.

Informal enquiries are encouraged and can be made to Andrew Loudon. Tel: +44 (0)161 275 3888; Fax +44 (0)161 275 3938; E-mail: [email protected]

Post is tenable from 1st September 2007 for 4 years

Application forms and further particulars can be obtained at or from

The Directorate of Human Resources
Tel: ++44 (0) 161 275 8836
Email: [email protected]

The University will actively foster a culture of inclusion and diversity and will seek to achieve true equality of opportunity for all members of its community.

This article comes from EUCLOCK - Entrainment of the circadian clock -

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