Human beings share a lot of the basic residential or commercial properties of circadian timing, consisting of the ability for selfsustained circadian organisation, entrainment by and also phase reaction to light stimuli with animals. This holds likewise for the physiological and also molecular organisation of circadian oscillators. Therefore, we can discover a lot from animal designs of circadian organisation, in particular from other animals.
Our objective is to obtain thorough understanding in the feedbacks of mice to entraining light as well as social signals at the behavioural, physiological and also molecular-genetic degrees - as a template for comprehending the human circadian problem. The Sub-Project focuses on both systems that mostly regulate circadian rhythmicity in the computer mouse.
To start with, the main pacemaker in the suprachiasmatic center (SCN). Light is the main zeitgeber entraining the SCN as well as thus behavioral rhythms. Second of all, the liver and various other body organs with independent circadian oscillators now seem entrained by feeding practices.
As long as the animal is totally free to feed at any time, the whole system is entrained by light via the sequence eyes- SCN- feeding practices- peripheral oscillator. When feeding is limited to other phases than chosen automatically, dys-entrainment between main as well as outer rhythmicity takes place.
Sub-Project Leader: Prof. Dr. Urs Albrecht, University of Fribourg, Department of Biochemistry and biology
Participants
- Prof. Dr. Serge Daan (Deputy Leader), College of Groningen, Chronobiology
- Prof. Dr. Domien Beersma, College of Groningen, Chronobiology
- Prof. Dr. Russell Foster, University of Oxford, Circadian and also Aesthetic Neuroscience
- Dr. Johanna H. Meijer, University of Leiden, Department of Neurophysiology
- Dr. Michael Hastings, Medical Research Council, Medical Research Council
- Prof. Dr. Ueli Schibler, University of Geneva, Department of Molecular Biology
- Dr. Alena Sumova, Academy of Scientific Research of the Czech Republic, Institute of Physiology
- Prof. Dr. Helena Illnerova, Academy of Science of the Czech Republic, Institute of Physiology
- Dr. Gijsbertus van der Horst, Erasmus MC-Rotterdam, Division of Cell Biology and also Genetics
- Dr. Emma Perfect, LUX Biotechnology
Uwe Strobel Lichtblick - Dr. Hans-Peter Lipp, NewBehavior